Kinetic determination of propranolol in tablets by oxidation with ceric sulphate.

S M Sultan, S A Altamrah, A M Aziz Alrahman, I Z Alzamil, M O Karrar

Index: J. Pharm. Biomed. Anal. 7(3) , 279-86, (1989)

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Abstract

A simple and accurate kinetic method for the determination of propranolol has been developed. Cerium(IV) sulphate (0.5 M) is used to oxidize propranolol in 2 M sulphuric acid at room temperature to the ketone form that absorbs light at a lambda max of 525 nm. The fixed-concentration method is used by recording the exact time, t(s), taken for the reaction to reach a fixed absorbance of 0.100. The unknown concentration, c(M), of propranolol is calculated from the equation: l/t = 0 0.000217 + 0.03 c. The method has been applied to the determination of propranolol in proprietary tablets and the results were compared with those obtained by the B.P. and other standard methods.