Cobalt??Catalyzed C–N Bond??Forming Reaction between N??Aromatic 2??Chlorides and Secondary Amines

G Toma, K Fujita, R Yamaguchi

Index: Toma, Gabriel; Fujita, Ken-Ichi; Yamaguchi, Ryohei European Journal of Organic Chemistry, 2009 , # 27 p. 4586 - 4588

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Citation Number: 19

Abstract

Abstract Secondary amines react with N-aromatic 2-chlorides in the presence of a catalytic amount of cobalt chloride. When DPPP was added as ligand, the yield was further improved. The N-aromatic-containing tertiary amines formed are interesting due to their potential biological activity. This work represents the first cobalt-catalyzed approach to C–N bond formation involving N-aromatic 2-chlorides and secondary amines having a certain ...