The anti-inflammatory activity of marine natural products--6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate.

P J Buckle, B A Baldo, K M Taylor

Index: Agents Actions 10(4) , 361-7, (1980)

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Abstract

Three novel marine substances, 6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate, isolated from a brown alga, a soft coral and a dictyoceratid sponge respectively, were active after oral administration in both acute and chronic animal models of inflammation. 6-n-Tridecylsalicylic acid has similar anti-inflammatory activity but less ulcerogenic activity on a molar basis than salicylic acid. The structure and activity of flexibilide did not resemble any known anti-inflammatory substance. Dendalone 3-hydroxybutyrate was a potent inhibitor of prostaglandin synthetase activity and platelet aggregation in vitro.