Antiproliferative activity of epi-cercosporin in human solid tumor cell lines.

Angel Trigos, César Espinoza, Maricela Martínez, Olivia Márquez, Leticia G León, José M Padrón, Manuel Norted, José J Fernández

Index: Nat. Prod. Commun. 8(2) , 187-9, (2013)

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Abstract

From cultures of Cercospora piaropi, a phytopathogenic fungus isolated from symptomatic leaves of water hyacinth was obtained a red compound, which, according to the spectroscopic data, was epi-cercosporin. It showed in vitro antiproliferative activity against the panel of human solid tumor cells HBL-100, HeLa, SW1573 and WiDr. Cell cycle studies revealed that epi-cercosporin induces accumulation of cells in G2/M phase.