Salicylanilide carbamates: antitubercular agents active against multidrug-resistant Mycobacterium tuberculosis strains.
Juana M Férriz, Katerina Vávrová, Filip Kunc, Ales Imramovský, Jirina Stolaríková, Eva Vavríková, Jarmila Vinsová
Index: Bioorg. Med. Chem. 18 , 1054-61, (2010)
Full Text: HTML
Abstract
A series of 27 salicylanilide-based carbamates was prepared as a part of our ongoing search for new antituberculosis drugs. These compounds exhibited very good in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium and, in particular, against five multidrug-resistant strains, with MIC values between 0.5-2 micromol/L. Moreover, they displayed moderate toxicity against intestinal cells with the selectivity index being up to 96. Furthermore, acid stability and a half-life of 43h at pH 7.4 were shown. Thus, these novel salicylanilide derivatives are drug candidates which should be seriously consider for further screening.Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Related Compounds
Related Articles:
2015-03-01
[Tuberculosis (Edinb.) 95(2) , 155-61, (2015)]
2014-12-01
[Tuberculosis (Edinb.) 94(6) , 701-7, (2015)]
2015-02-01
[PLoS Pathog. 11(2) , e1004645, (2015)]
In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis.
2015-01-01
[Antimicrob. Agents Chemother. 59(1) , 136-44, (2014)]
Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine.
2015-04-01
[J. Appl. Microbiol. 118(4) , 864-72, (2015)]