Efficient terpene hydroxylation catalysts based upon P450 enzymes derived from actinomycetes.
Ayhan Celik, Sabine L Flitsch, Nicholas J Turner
Index: Org. Biomol. Chem. 3(16) , 2930-4, (2005)
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Abstract
The hydroxylation of alpha-ionone 1 and beta-ionone 2 to their corresponding mono-hydroxylated derivatives has been examined using a recombinant E. coli whole cell system, in which cytochromes P450 SU1 and SU2, and P450 SOY were over-expressed with their cognate ferrodoxins. Both substrates are hydroxylated with a high degree of regioselectivity and for alpha-ionone 1 the reaction is highly diastereoselective yielding the anti-isomer.
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