Tetrahedron

Bromination of phenols in bromoperoxidase-catalyzed oxidations

D Wischang, J Hartung

Index: Wischang, Diana; Hartung, Jens Tetrahedron, 2012 , vol. 68, # 46 p. 9456 - 9463

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Citation Number: 13

Abstract

Phenol and ortho-substituted derivatives furnish products of selective para-bromination, if treated with sodium bromide, hydrogen peroxide, and the vanadate (V)-dependent bromoperoxidase I from the brown alga Ascophyllum nodosum. Relative rates of bromination in morpholine-4-ethane sulfonic acid (MES)-buffered aqueous tert-butanol (pH 6.2) increase by a factor 32, as the ortho-substituent in a phenol changes from F via Cl, ...