Rosmarinus officinalis L. essential oil inhibits in vivo and in vitro leukocyte migration.
Gessilda Alcantara Nogueira de Melo, Renata Grespan, Jefferson Pitelli Fonseca, Thiago Oliveira Farinha, Expedito Leite Silva, Adriano Lopes Romero, Ciomar A Bersani-Amado, Roberto Kenji Nakamura Cuman
Index: J. Med. Food 14(9) , 944-6, (2011)
Full Text: HTML
Abstract
Rosmarinus officinalis L. (Lamiaceae), popularly known as rosemary, is used for food flavoring and in folk medicine as an antispasmodic, analgesic, antirheumatic, diuretic, and antiepileptic agent. Few studies have shown the anti-inflammatory effects of rosemary essential oil (REO). This study evaluated the effects of REO on leukocyte migration through in vivo leukocyte migration and in vitro chemotaxis assay. REO was analyzed by using gas chromatography-mass spectometry, and the main components identified were camphor (27.59%), 1,8-cineole (15.74%), α-pinene (16.58%), and β-myrcene (10.02%). In rats, administration of REO reduced the number of leukocytes that rolled, adhered, and migrated to the scrotal chamber after carrageenan injection. All doses of REO tested significantly inhibited leukocyte chemotaxis induced by casein. The effects of REO on leukocyte migration highlight an important mechanism of the anti-inflammatory action of rosemary.
Related Compounds
Related Articles:
2010-10-01
[Food Microbiol. 27(7) , 889-96, (2010)]
2013-10-01
[Meat Science 95(2) , 235-41, (2013)]
Trial of a minimal-risk botanical compound to control the vector tick of Lyme disease.
2010-07-01
[J. Med. Entomol. 47(4) , 695-8, (2010)]
Prevention of retinal light damage by zinc oxide combined with rosemary extract.
2013-01-01
[Mol. Vis. 19 , 1433-45, (2013)]
Investigations into the specific effects of rosemary oil at the receptor level.
2010-07-01
[Phytomedicine 17(8-9) , 693-7, (2010)]