Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists

N Kaila, K Janz, S DeBernardo…

Index: Journal of Medicinal Chemistry, , vol. 50, # 1 p. 21 - 39

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Citation Number: 86

Abstract

... Journal of Medicinal ... High-throughput screening of the Wyeth chemical library identified the quinoline salicylic acid class of compounds (1) as antagonists of ... potency in in vitro and cell-based assays far superior to that of sLe x . Through iterative medicinal chemistry, we identified ...