Stereoselektive Synthese des substituierten Morphan??Gerüstes ausgehend von 4??Acetamidocyclohexanon

HJ Teuber, C Tsaklakidis…

Index: Teuber, Hans-Joachim; Tsaklakidis, Christos; Bats, Jan Willem Liebigs Annalen der Chemie, 1990 , # 8 p. 781 - 787

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Abstract

4-Acetamidocyclohexanone (2), prepared from 4-acetamido-6 or the cyclised aldol 5b (5a from 4a, respectively) with cyclohexanol (l), has been transformed into the ethyleneacetal 2- azabicyclo [3.3. 1] nonane structure and endo-positioned hy-3b which was amidated with pyruvic and 2-oxobutyric acid droxy group. Constitution and stereochemistry has been to give 3c and d, respectively. After removal of the protecting proved by X-ray structure ...