Annelation of Baylis–Hillman derivatives: synthesis of highly functionalised tetrahydronaphthalenes
A J'mour, F Rezgui
Index: J'mour, Asma; Rezgui, Farhat Journal of Chemical Research, 2009 , # 10 p. 642 - 644
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Abstract
PTSA-promoted Robinson annelation of α-(3-oxobutyl) cyclohex-2-en-1-one derivatives in refluxing toluene, affords efficiently in a one pot process a variety of hydroxytetrahydronaphthyl carbonyl compounds in good yields. Further highly regioselective electrophilic bromination of these intermediates gave the corresponding bromide derivatives in 92–97% yield.
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