Bioorganic & Medicinal Chemistry Letters 2008-11-01

Synthesis and free radical scavenging activity of some new spiropyranocoumarins.

Vassiliki Panteleon, Ioannis K Kostakis, Panagiotis Marakos, Nicole Pouli, Ioanna Andreadou

Index: Bioorg. Med. Chem. Lett. 18 , 5781-4, (2008)

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Abstract

A series of novel spiro-substituted 4-hydroxypyranocoumarins and their corresponding dihydropyrano cis-diols has been synthesized. Among them the spiroadamantylpyranocoumarin and the diols can interact with the stable free radical 1,1-diphenyl-2-picrylhydrazyl and scavenge superoxide anions generated in the xanthine-xanthine oxidase system.

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