A new diversity oriented and metal-free approach to highly functionalized 3 H-pyrimidin-4-ones

R Riva, L Banfi, A Basso, P Zito

Index: Riva, Renata; Banfi, Luca; Basso, Andrea; Zito, Paola Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2107 - 2122

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Citation Number: 3

Abstract

A new synthesis of 3H-pyrimidin-4-ones, characterized by four different sets of decorations, is presented. The strategy is based on the synthetic elaboration of readily available α- substituted β-ketoesters that, upon transformation into the corresponding acyl enamines, have been cyclized to give 6H-1, 3-oxazin-6-ones. These reactive intermediates have been in turn cleanly converted into highly functionalized pyirimidinones, by treatment with an ...