Chemico-Biological Interactions 1993-02-01

1H-NMR study of suloctidil-A23187 calcium ionophore interaction.

A M Chauvet-Monges, R Faure, A Crevat

Index: Chem. Biol. Interact. 86(2) , 163-9, (1993)

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Abstract

Suloctidil is a molecule with calcium antagonist properties, whose anti-ionophoretic effect has previously been reported. In the presence of A23187 calcium ionophore free acid (A+), the NMR spectra of suloctidil (S +/-) are modified at the level of H-1 protons and to a lesser degree in the CH3-3 and aromatic regions. Experiments with one of the enantiomers of suloctidil and decoupling investigations led us to postulate the existence of diastereoisomers S+/A+, S-/A+ in the suloctidil +/-/A23187 + mixture. Moreover our results allow the hypothesis that suloctidil and calcium compete for the same binding site of the ionophore molecule.

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