Synlett

An efficient synthesis of N-arylputrescines and cadaverines

NP Link, JE Díaz, LR Orelli

Index: Link, Natalia P.; Diaz, Jimena E.; Orelli, Liliana R. Synlett, 2009 , # 5 p. 751 - 754

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Citation Number: 7

Abstract

Abstract We present a two-step, general synthesis of N-arylputrescines and cadaverines, by cesium carbonate mediated alkylation of anilines with ω-chloronitriles and subsequent reduction. The cesium-mediated alkylation shows remarkable selectivity towards the monoalkylation product. The method is straightforward and leads to satisfactory global yields.

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