Synthesis of indoles by intermolecular cyclization of unfunctionalized nitroarenes and alkynes, catalyzed by palladium-phenanthroline complexes
…, A Rapetti, E Visentin, M Monzani…
Index: Ragaini, Fabio; Rapetti, Andrea; Visentin, Elena; Monzani, Michela; Caselli, Alessandro; Cenini, Sergio Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 3748 - 3753
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Citation Number: 72
Abstract
Palladium-phenanthroline complexes efficiently catalyze the reaction of nitroarenes with arylalkynes and CO to give 3-arylindoles by an ortho-CH functionalization of the nitroarene ring. Both electron-withdrawing and electron-donating substituents are tolerated on the nitroarene, except for bromide and activated chloride. Nitroarenes bearing electron- withdrawing substituents react faster, but the selectivity of the reaction depends on both ...
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