… -activity relationships of 1, 4-dihydro-(1H, 4H)-quinoxaline-2, 3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists. 1. Heterocyclic substituted 5-alkyl …
MJ Fray, DJ Bull, CL Carr, ECL Gautier…
Index: Abenhaim, David; Diez-Barra, Enrique; Hoz, Antonio de la; Loupy, Andre; Sanchez-Migallon, Ana Heterocycles, 1994 , vol. 38, # 4 p. 793 - 802
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Citation Number: 57
Abstract
... Binding affinity increased significantly if the heterocyclic group, eg 1,2,3-triazol-1-yl ... compounds (1−17) (Chart 2) in which the hydrogen bond acceptor is an aromatic heterocycle. ... were most conveniently prepared by reaction of the benzylic bromide 35 with heterocycles such as ...
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