Pharmazie 1982-05-01

[Synthesis and antibacterial and antitumoral activity of some methylhydrazonium salts of pyrimidine bases and their analogues (author's transl)].

E Golovinsky, G Karamanov, N Spassovska, L Maneva, A Spassov

Index: Pharmazie 37 , 355-356, (1982)

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Abstract

On reacting pyrimidine metabolites containing a carboxyl or sulfhydryl group with methylhydrazine or N-benzyl-N'-methylhydrazine, various methylhydrazonium salts of these metabolites were synthetized, e.g., the salts of 5-fluororotic acid, 5-azaorotic acid, 2-thiouracil-5-carboxylic acid and 2-thio-6-azathymine. Some of these salts exhibited a more marked antibacterial activity against St. aureus and several of its mutants as well as a greater antitumoral activity against different transplantable tumours than their single components.