Journal of heterocyclic chemistry

Reactions of derivatives of anthranilic acid with 3??chloropropyl isocyanate

EP Papadopoulos

Index: Papadopoulos, E. P. Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1411 - 1414

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Citation Number: 11

Abstract

Abstract The urea 1 obtained from anthranilonitrile and 3-chloropropyl isocyanate is converted into 3-(3-chloropropyl)-2, 4 (1H, 3H) quinazolinedione (4) when heated with hydrochloric acid, whereas it undergoes a double cyclization to form 2, 3, 4, 7-tetrahydro-6H- pyrimido [1, 2-c] quinazolin-6-one (3) upon heating, or treatment with ammonia. On the other hand, the urea 5 formed from methyl anthranilate and 3-chloropropyl isocyanate cyclizes ...