Synthesis and Antimycobacterial Evaluation of Novel Phthalazin??4??ylacetamides Against log??and Starved Phase Cultures

D Sriram, P Yogeeswari, P Senthilkumar…

Index: Sriram, Dharmarajan; Yogeeswari, Perumal; Senthilkumar, Palaniappan; Sangaraju, Dewakar; Nelli, Rohit; Banerjee, Debjani; Bhat, Pritesh; Manjashetty, Thimmappa H. Chemical Biology and Drug Design, 2010 , vol. 75, # 4 p. 381 - 391

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Citation Number: 16

Abstract

Twenty four novel 2-[3-(4-bromo-2-fluorobenzyl)-4-oxo-3, 4-dihydro-1-phthalazinyl] acetic acid amides were synthesized from phthalic anhydride and were subjected to in vitro and in vivo evaluation against log-and starved phase of mycobacterial species and Mycobacterium tuberculosis isocitrate lyase enzyme inhibition studies. Among the compounds screened, 2- (2-(4-bromo-2-fluorobenzyl)-1, 2-dihydro-1-oxophthalazin-4-yl)-N-(2, 6-dimethylphenyl) ...