The Journal of Organic Chemistry

An efficient and versatile method for the synthesis of optically active 2-oxazolines: an acid-catalyzed condensation of ortho esters with amino alcohols

K Kamata, I Agata, AI Meyers

Index: Kamata, Kazuyuki; Agata, Isao; Meyers, A. I. Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 3113 - 3116

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Citation Number: 87

Abstract

A variety of methods have been reported for the synthesis of enantiomerically pure 2- oxazolines which currently play an important role in asymmetric synthesis as chiral auxiliaries1 and more recently as ligands2 for catalytic asymmetric reactions. Commonly employed literature procedures for the preparation of chiral 2-oxazolines include condensation of 2-amino alcohols with alkyl imidates, 1 cyclization of hydroxyl amides, 1, ...