Bioorganic & Medicinal Chemistry Letters 2007-06-01

Formation of an enolate intermediate is required for the reaction catalyzed by 3-hydroxyacyl-CoA dehydrogenase.

Xiaojun Liu, Guisheng Deng, Xiusheng Chu, Nan Li, Long Wu, Ding Li

Index: Bioorg. Med. Chem. Lett. 17(11) , 3187-90, (2007)

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Abstract

Fluorinated substrate analogs were synthesized and incubated with rat liver 3-hydroxyacyl-CoA dehydrogenase, which reveals that the formation of an enolate intermediate is required for the reaction catalyzed by the enzyme.