Genotoxicity and transmission electron microscopy studies of molybdocene dichloride.
Kate S Campbell, Amalanie J Foster, Carolyn T Dillon, Margaret M Harding
Index: J. Inorg. Biochem. 100(7) , 1194-8, (2006)
Full Text: HTML
Abstract
The cytotoxic effects of molybdocene dichloride (Cp(2)MoCl(2)) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. Cp(2)MoCl(2) produced significant genotoxic damage whereby 0.2micronuclei/1000 binucleated cells were induced per muM of Cp(2)MoCl(2). Transmission electron microscopic analysis of thin-sectioned cells treated with Cp(2)MoCl(2) (300microM) showed distinct morphological alterations of the nuclei, condensation of chromatin, and a high incidence of polynucleated cells. Implications for the mechanism of antitumor action of molybdocene dichloride are discussed.
Related Compounds
Related Articles:
2007-08-28
[Dalton Trans. (32) , 3474-82, (2007)]
Coordination chemistry of the antitumor metallocene molybdocene dichloride with biological ligands.
2004-01-12
[Inorg. Chem. 43(1) , 206-13, (2004)]
2005-03-24
[J. Med. Chem. 48(6) , 2093-9, (2005)]
Inclusion complexes of the antitumour metallocenes Cp(2)MCl(2) (M = Mo, Ti) with cucurbit[n]urils.
2008-05-07
[Dalton Trans. (17) , 2328-34, (2008)]
A (1)H NMR study of the interaction of antitumor metallocenes with glutathione.
2001-09-01
[J. Inorg. Biochem. 86(2-3) , 611-6, (2001)]