Carbohydrate research

Synthesis of 5-amino-5-deoxy-d-mannopyranose and 1, 5-di-deoxy-1, 5-imino-d-mannitol, and inhibition of α-and β-d-mannosidases

G Legler, E Jülich

Index: Legler, Guenter; Juelich, Elisabeth Carbohydrate Research, 1984 , vol. 128, p. 61 - 72

Full Text: HTML

Citation Number: 175

Abstract

Abstract The title compounds and the corresponding l-gulo derivatives were synthesised in 6 steps from benzyl 2, 3: 5, 6-di-O-isopropylidene-α-d-mannofuranoside. The K i values, determined from inhibition studies with α-d-mannosidases from jack beans, almonds, and calf liver, and β-d-mannosidase from Aspergillus wentii, ranged from 70 to 400μM for the mannitol derivative and from 1.2 to 20μM for 5-amino-5-deoxy-d-mannopyranose, ie, ...