Medicinal Chemistry Research

Synthesis and evaluation of meta substituted 1-(aryloxypropyl)-4-(chloroaryl) piperazines as potential atypical antipsychotics

A Bali, ACDK Reddy

Index: Bali, Alka; Reddy, A. C. Dinesh Kumar Medicinal Chemistry Research, 2013 , vol. 22, # 1 p. 382 - 391

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Citation Number: 2

Abstract

Abstract A series of 1-(aryloxypropyl)-4-(chloroaryl) piperazines have been synthesized based upon their physicochemical similarity with respect to standard atypical antipsychotic drugs and their potential to cross the blood–brain barrier (log BB) as calculated by appropriate software programmes. The target compounds were evaluated for atypical antipsychotic activity in apomorphine-induced mesh climbing and stereotypy assays in ...