Synthesis, tubulin binding, antineoplastic evaluation, and structure-activity relationship of oncodazole analogs

LI Kruse, DL Ladd, PB Harrsch…

Index: Journal of Medicinal Chemistry, , vol. 32, # 2 p. 409 - 417

Full Text: HTML

Citation Number: 69

Abstract

... Chemical reduction of 62 and 63 followed by cyclization yielded 25 and 26. The 4'- [ (trifluoromethyl)carbonyl]thiophene analogue 28 was prepared from the previously reported5 interme- Page 4. 412 Journal of Medicinal Chemistry, 1989, Vol. 32, No. 2 ...