One pot conjugation of the polypeptides directed by phosphorus oxychloride.
N Zhou, Y Liu, G J Zhou, Y F Zhao
Index: J. Pept. Res. 65(4) , 427-32, (2005)
Full Text: HTML
Abstract
A series of homopeptides and their conjugates were synthesized in one pot reaction in the presence of phosphorus oxychloride and the conjugate yield was structurally dependent. Menthol and benzylamine conjugated to the homopeptides quantitatively. Homopeptides when treated with diisopropyloxyphosphite (DIPPH) and NaClO yield the corresponding N-phosphoryl peptides. Electrospray ionization-mass spectrometry (ESI-MS)/MS was used to study the structure of peptide conjugates. This paper reports a simple method to synthesize the homopeptides and their conjugate derivatives and the fact that phosphoryl peptides could also be obtained by one pot reaction.
Related Compounds
Related Articles:
2014-01-01
[Faraday Discuss. 174 , 313-39, (2014)]
Toughened hydrogels inspired by aquatic caddisworm silk.
2015-09-21
[Soft Matter 11 , 6981-90, (2015)]
2003-11-14
[J. Biol. Chem. 278(46) , 45512-8, (2003)]
POCl3 chlorination of 4-quinazolones.
2011-03-18
[J. Org. Chem. 76(6) , 1653-61, (2011)]
Facile small scale synthesis of nucleoside 5'-phosphate mixtures.
2010-01-01
[Nucleosides Nucleotides Nucleic Acids 29(1) , 14-26, (2010)]