Electrospray ionization mass spectrometric studies of phosphorus oxychloride directed synthesis of homo-oligopeptide ester libraries.

Ning Zhou, Kui Lu, Yan Liu, Yi Chen, Guo Tang, Shu-Xia Cao, Ling-Bo Qu, Yu-Fen Zhao

Index: Rapid Commun. Mass Spectrom. 16(10) , 919-22, (2002)

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Abstract

With the assistance of phosphorus oxychloride, alpha-amino acids were assembled into homo-peptides, which were analyzed by electrospray ionization mass spectrometry (ESI-MS) and multistage electrospray ionization mass spectrometry (ESI-MS/MS). On quenching with water or various alcohols, the reaction mixtures yielded the corresponding peptides or peptide esters, respectively. This paper reports a simple method to synthesize the homo-oligo-peptide-ester conjugated library by phosphorus oxychloride activation.Copyright 2002 John Wiley & Sons, Ltd.