Synthetic Anticonvulsants. The Preparation and Properties of Some Benzoxazoles1

WG Bywater, WR Coleman, O Kamm…

Index: Bywater et al. Journal of the American Chemical Society, 1945 , vol. 67, p. 905

Full Text: HTML

Citation Number: 50

Abstract

There is some evidence that in certain series of compounds having hypnotic activity, higher molecular weight members possess anticonvulsant activity without inducing a hypnotic effect, ie, the change from 5-phenyl-5-ethylhydantoin to dilantin (5, 5-diphenylhydantoin) resulted in a greatly increased convulsive threshold and no hypnotic effect. This observation prompted us to investigate the benzoxazoles for three reasons. First, benzoxazolone (2- ...

Related Articles:

A green route for the synthesis of 2-substituted benzoxazole derivatives catalyzed by Al 3+-exchanged K10 clay

[Suresh, Dhanusu; Dhakshinamoorthy, Amarajothi; Pitchumani, Kasi Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6415 - 6419]

Poly (ethylene glycol)-bound sulphonic acid as a novel catalyst for synthesis of benzoxazoles

[Chikhale, Rupesh V.; Pant, Amit M.; Menghani, Sunil S.; Wadibhasme, Pankaj G.; Khedekar, Pramod B. South African Journal of Chemistry, 2013 , vol. 66, p. 254 - 262]

Copper-catalyzed synthesis of benzoxazoles via a regioselective C− H functionalization/C− O bond formation under an air atmosphere

[Ueda, Satoshi; Nagasawa, Hideko Journal of Organic Chemistry, 2009 , vol. 74, # 11 p. 4272 - 4277]

Direct arylation of benzoxazole C–H bonds with iodobenzene diacetates

[Yu, Peng; Zhang, Guangyou; Chen, Fan; Cheng, Jiang Tetrahedron Letters, 2012 , vol. 53, # 34 p. 4588 - 4590]

Parallel synthesis of a library of benzoxazoles and benzothiazoles using ligand-accelerated copper-catalyzed cyclizations of ortho-halobenzanilides

[Evindar, Ghotas; Batey, Robert A. Journal of Organic Chemistry, 2006 , vol. 71, # 5 p. 1802 - 1808]

More Articles...