A practical preparation of terminal alkynes from aldehydes

Z Wang, S Campagna, K Yang, G Xu…

Index: Wang, Zhe; Campagna, Silvio; Yang, Kaihong; Xu, Guoyou; Pierce, Michael E.; Fortunak, Joseph M.; Confalone, Pat N. Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1889 - 1891

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Citation Number: 60

Abstract

As a part of the project for the development of an economical and efficient synthesis of Efavirenz (Sustiva, DMP 266), a marketed nonnucleoside reverse transcriptase inhibitor of the HIV-1 virus developed by our company for the treatment of AIDS, 1 we have searched for new methodologies for the synthesis of cyclopropylacetylene 1 (CPA). As discussed previously, 2 we anticipated that the most efficient synthesis of 1 would occur from ...