Deglycobleomycin A 6 analogues modified in the methylvalerate moiety
X Cai, PA Zaleski, A Cagir, SM Hecht
Index: Cai, Xiaoqing; Zaleski, Paul A.; Cagir, Ali; Hecht, Sidney M. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 12 p. 3831 - 3844
Full Text: HTML
Citation Number: 5
Abstract
Abstract Previous studies have indicated that the methylvalerate subunit of bleomycin (BLM) plays an important role in facilitating DNA cleavage by BLM and deglycoBLM. Eleven methylvalerate analogues have been synthesized and incorporated into deglycoBLM congeners by the use of solid-phase synthesis. The effect of the valerate moiety in the deglycoBLM analogues has been studied by comparison with the parent deglycoBLM A 5 ...
Related Articles:
Total synthesis of the polyether antibiotic ionomycin
[Journal of the American Chemical Society, , vol. 112, # 13 p. 5290 - 5313]
Interaction Modes of Titanium Tetrachloride with the Carbonyl Functionality
[Chemische Berichte, , vol. 129, # 11 p. 1361 - 1368]
One pot synthesis of N-derivatized 2-oxazolidinones from amino alcohol carbamates
[Tetrahedron Letters, , vol. 35, # 51 p. 9533 - 9536]
Chemoselective N??Acylation of Indoles and Oxazolidinones with Carbonylazoles
[Heller, Stephen T.; Schultz, Erica E.; Sarpong, Richmond Angewandte Chemie - International Edition, 2012 , vol. 51, # 33 p. 8304 - 8308]
Absolute Configuration of Lactams and Oxazolidinones Using Kinetic Resolution Catalysts
[Organic Letters, , vol. 15, # 3 p. 472 - 475]