Synthesis of Regioisomeric Pyrido [c] azocanones from Azaindanone Derivatives

M Penning, J Christoffers

Index: Penning, Miriam; Christoffers, Jens European Journal of Organic Chemistry, 2014 , vol. 2014, # 10 p. 2140 - 2149

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Abstract

Abstract A ring enlargement reaction with methylamine gave new pyrido [2, 3-c]-, pyrido [3, 4- c]-and pyrido [3, 2-c] azocanone derivatives from cyclic β-oxo esters with a cyclopentapyridine skeleton and a 1, 4-diketone moiety. The starting materials for this ring transformation were either prepared from halogenopyridine carboxylates by Heck reaction and subsequent hydrogenation, or (halogenomethyl) pyridine carboxylates were ...