Microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues.

Andreas Lanver, Hans-Günther Schmalz

Index: Molecules 10(2) , 508-15, (2005)

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Abstract

An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir analogues) starting from commercially available compounds.