Organic Letters 2012-05-04

Direct palladium(II)-catalyzed synthesis of arylamidines from aryltrifluoroborates.

Jonas Sävmarker, Jonas Rydfjord, Johan Gising, Luke R Odell, Mats Larhed

Index: Org. Lett. 9th ed., 14 , 2394-2397, (2012)

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Abstract

A fast and convenient synthesis of arylamidines starting from readily available potassium aryltrifluoroborates and cyanamides is reported. The coupling was achieved by Pd(II)-catalysis in a one step 20 min microwave protocol using Pd(O(2)CCF(3)), 6-methyl-2,2'-bipyridyl, TFA, and MeOH, providing the corresponding arylamidines in moderate to excellent yields.

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