[Lanthanides induce neurotransmitter release from the vesicular pool in rat brain synaptosomes].

L P Lopatina, T V Vasim, S V Fedorovich, S V Konev

Index: Biofizika 50(6) , 1120-4, (2005)

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Abstract

The influence of lanthanoids on exocytosis was investigated. It was shown that gadolinium increases the spontaneous release of the glutamate nonmetabolizing analogue [3H]D-aspartate. It was established using the fluorescent dye acridine orange that gadolinium and lanthanum induce exocytosis. The effect was dose-dependent and was maximum at 300 microM Gd3+. The exocytosis induced by gadolinium was calcium-independent. It is suggested that lanthanides induce a vesicular release of neurotransmitters by the mechanisms common for all polyvalent cations.