Facile synthesis of peptide–porphyrin conjugates: Towards artificial catalase

N Umezawa, N Matsumoto, S Iwama, N Kato…

Index: Umezawa, Naoki; Matsumoto, Nobuyoshi; Iwama, Shinsuke; Kato, Nobuki; Higuchi, Tsunehiko Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 17 p. 6340 - 6350

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Citation Number: 34

Abstract

A facile synthetic method for peptide–porphyrin conjugates containing four peptide units on one porphyrin was developed using chemoselective reactions. The key building blocks, 5, 10, 15, 20-tetrakis (3-azidophenyl) porphyrin 1 and 5, 10, 15, 20-tetrakis (5-azido-3-pyridyl) porphyrin 2, were efficiently synthesized and used as substrates for two well-known chemoselective reactions, traceless Staudinger ligation and copper-catalyzed azide ...