Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity …

L Wang, KW Woods, Q Li, KJ Barr…

Index: Journal of Medicinal Chemistry, , vol. 45, # 8 p. 1697 - 1711

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Citation Number: 377

Abstract

... Journal of Medicinal ... Global Pharmaceutical R & D, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6101. J. Med ... CA-4. 4,5-Disubstituted imidazole was found to be the best for the replacement of the cis double bond in CA-4. Medicinal chemistry efforts led ...