Journal of Addiction Medicine 2011-12-01

Neuroleptic malignant syndrome-like reaction precipitated by antipsychotics in a patient with gamma-butyrolactone withdrawal.

Céline Eiden, Delphine Capdevielle, Charlotte Deddouche, Jean-Philippe Boulenger, Jean-Pierre Blayac, Hélène Peyrière

Index: J. Addict. Med. 5(4) , 302-3, (2011)

Full Text: HTML

Abstract

We report the case of a patient with chronic abuse of gamma-butyrolactone (GBL, 3 bottles per week for 4 months), who in the course of the management of acute agitation and hallucinations developed symptoms compatible with both neuroleptic malignant syndrome and GBL withdrawal symptoms.Some GHB withdrawal symptoms are similar to those of neuroleptic malignant syndrome, and the administration of antipsychotics might worsen the neurological condition of patients. So, it seems important to rapidly detect drugs taken by patients with mental agitation, to optimize management and minimize complications related to drugs.

Related Compounds

Related Articles:

Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC–MS/MS

2012-01-01

[J. Pharm. Biomed. Anal. 58 , 83-93, (2012)]

In vitro aerosol characterization of Staccato(®) Loxapine.

2011-01-17

[Int. J. Pharm. 403(1-2) , 101-8, (2011)]

Inhaled loxapine for agitation revisited: focus on effect sizes from 2 Phase III randomised controlled trials in persons with schizophrenia or bipolar disorder.

2012-03-01

[Int. J. Clin. Pract. 66(3) , 318-25, (2012)]

The pharmacoepidemiology of antipsychotics for adults with schizophrenia in Canada, 2005 to 2009.

2011-10-01

[Can. J. Psychiatry. 56(10) , 630-4, (2011)]

Interaction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study.

2011-02-01

[J. Comput. Aided Mol. Des. 25(2) , 163-9, (2011)]

More Articles...