An efficient deprotection of N-trimethylsilylethoxymethyl (SEM) groups from dinucleosides and dinucleotides.

Tilak Chandra, William E Broderick, Joan B Broderick

Index: Nucleosides Nucleotides Nucleic Acids 29(2) , 132-43, (2010)

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Abstract

A convenient and efficient method for deprotection of N-(trimethyl)silylethoxymethyl (SEM) groups from thymidine dinucleoside and dinucleotide has been achieved. The SEM groups were easily removed in excellent yields from protected nucleosides, dinucleosides, and dinucleotides.