Helvetica chimica acta

Preparation of N??Fmoc??Protected β2??and β3??Amino Acids and their use as building blocks for the solid??phase synthesis of β??peptides

G Guichard, S Abele, D Seebach

Index: Guichard, Gilles; Abele, Stefan; Seebach, Dieter Helvetica Chimica Acta, 1998 , vol. 81, # 2 p. 187 - 206

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Citation Number: 180

Abstract

Abstract N-Fmoc-Protected (Fmoc=(9H-fluoren-9-ylmethoxy) carbonyl) β-amino acids are required for an efficient synthesis of β-oligopeptides on solid support. Enantiomerically pure Fmoc-β 3-amino acids β 3: side chain and NH 2 at C (3)(= C (β)) were prepared from Fmoc- protected (S)-and (R)-α-amino acids with aliphatic, aromatic, and functionalized side chains, using the standard or an optimized Arndt-Eistert reaction sequence. Fmoc-β 2-Amino ...