Synthesis and biological evaluation of 2, 8-disubstituted 9-benzyladenines: discovery of 8-mercaptoadenines as potent interferon-inducers

K Hirota, K Kazaoka, H Sajiki

Index: Hirota, Kosaku; Kazaoka, Kazunori; Sajiki, Hironao Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2715 - 2722

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Citation Number: 19

Abstract

Recently, we have identified 9-benzyl-8-hydroxyadenines bearing an appropriate substituent (a butoxy, propylthio or butylamino group) at the 2-position as potent interferon (IFN)-inducers. Herein we report the design, synthesis, and IFN-inducing activity of 8- substituted 9-benzyladenines possessing such an appropriate substituent at the 2-position. Introduction of the appropriate substituent into the 2-position of the adenine nucleus gave ...