Fully enzymatic N→ C??directed peptide synthesis using C??terminal peptide α??carboxamide to ester interconversion
T Nuijens, E Piva, JAW Kruijtzer…
Index: Nuijens, Timo; Piva, Elena; Kruijtzer, John A. W.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Quaedflieg, Peter J. L. M. Advanced Synthesis and Catalysis, 2011 , vol. 353, # 7 p. 1039 - 1044
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Citation Number: 12
Abstract
Abstract Chemoenzymatic peptide synthesis is potentially the most cost-efficient technology for the synthesis of short and medium-sized peptides with some important advantages. For instance, stoichiometric amounts of expensive coupling reagents are not required and racemisation does not occur rendering purification easier compared to chemical peptide synthesis. In this paper, a novel interconversion reaction of peptide C-terminal α- ...
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