Synthesis and evaluation of compounds that induce readthrough of premature termination codons
ME Jung, JM Ku, L Du, H Hu, RA Gatti
Index: Jung, Michael E.; Ku, Jin-Mo; Du, Liutao; Hu, Hailiang; Gatti, Richard A. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5842 - 5848
Full Text: HTML
Citation Number: 28
Abstract
A structure–activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these also showed good readthrough activity.
Related Articles:
Potent and orally bioavailable noncysteine-containing inhibitors of protein farnesyltransferase
[Augeri, David J.; Janowick, Dave; Kalvin, Douglas; Sullivan, Gerry; Larsen, John; Dickman, Daniel; Ding, Hong; Cohen, Jerry; Lee, Jang; Warner, Robert; Kovar, Peter; Cherian, Sajeev; Saeed, Badr; Zhang, Haichao; Tahir, Steve; Ng, Shi-Chung; Sham, Hing; Rosenberg, Saul H. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 8 p. 1069 - 1074]
Potent and orally bioavailable noncysteine-containing inhibitors of protein farnesyltransferase
[Augeri, David J.; Janowick, Dave; Kalvin, Douglas; Sullivan, Gerry; Larsen, John; Dickman, Daniel; Ding, Hong; Cohen, Jerry; Lee, Jang; Warner, Robert; Kovar, Peter; Cherian, Sajeev; Saeed, Badr; Zhang, Haichao; Tahir, Steve; Ng, Shi-Chung; Sham, Hing; Rosenberg, Saul H. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 8 p. 1069 - 1074]