Journal of Medicinal Chemistry 1989-10-01

Potential antiatherosclerotic agents. 6. Hypocholesterolemic trisubstituted urea analogues.

V G DeVries, J D Bloom, M D Dutia, A S Katocs, E E Largis

Index: J. Med. Chem. 32 , 2318, (1989)

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Abstract

The discovery that a series of N,N-dialkyl-N'-arylureas were inhibitors of the ACAT enzyme has led to a structure-activity study involving the systematic modification of three sites of the urea backbone. This study culminated in the selection of N'-(2,4-dimethylphenyl)-N-benzyl-N-n-butylurea (115) for more extensive biological evaluation. ACAT inhibitors are seen as potentially beneficial agents against hypercholesterolemia and atherosclerosis.