Comparative mutagenicity of 2-methylpropene (isobutene), its epoxide 2-methyl-1,2-epoxypropane and propylene oxide in the in vitro micronucleus test using human lymphocytes.
U Jorritsma, M Cornet, P Van Hummelen, H M Bolt, A Vercruysse, M Kirsch-Volders, V Rogiers
Index: Mutagenesis 10(2) , 101-4, (1995)
Full Text: HTML
Abstract
2-Methylpropene (isobutene), a gaseous compound widely used in chemical industries, is metabolized to the epoxide 2-methyl-1,2-epoxypropane. The parent compound has previously been shown to be non-mutagenic in a modified Ames test, whereas the epoxide metabolite gave a positive result. In this study, both compounds have been tested in the in vitro micronucleus test using human lymphocytes. Propylene oxide, a well known mutagenic compound, served as a positive control. It was found that 2-methylpropene had no mutagenic effect, whereas its epoxide induced a statistically significant dose-dependent increase in the number of micronuclei. The effect observed was comparable with that obtained for propylene oxide.
Related Compounds
Related Articles:
1992-06-01
[Mutat. Res. 271(3) , 213-21, (1992)]
In vitro biotransformation of 2-methylpropene (isobutene): epoxide formation in mice liver.
1991-01-01
[Arch. Toxicol. 65(4) , 263-7, (1991)]
Metabolism and toxicity of 2-methylpropene (isobutene)--a review.
1997-05-01
[Crit. Rev. Toxicol. 27(3) , 223-32, (1997)]
Species-dependent differences in biotransformation pathways of 2-methylpropene (isobutene).
1995-01-01
[Chem. Res. Toxicol. 8(7) , 987-92, (1995)]
Protonated 2-methyl-1,2-epoxypropane: a challenging problem for density functional theory.
2006-02-17
[J. Org. Chem. 71(4) , 1592-7, (2006)]