Mechanism??Inspired Engineering of Phenylalanine Aminomutase for Enhanced β??Regioselective Asymmetric Amination of Cinnamates
B Wu, W Szymański, GG Wybenga…
Index: Wu, Bian; Szymanski, Wiktor; Wybenga, Gjalt G.; Heberling, Matthew M.; Bartsch, Sebastian; Dewildeman, Stefaan; Poelarends, Gerrit J.; Feringa, Ben L.; Dijkstra, Bauke W.; Janssen, Dick B. Angewandte Chemie - International Edition, 2012 , vol. 51, # 2 p. 482 - 486
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Citation Number: 23
Abstract
In the last decade, enormous progress has been made in the synthesis of optically pure β- amino acids, which occur as components of numerous bioactive compounds.[1] Although biocatalytic routes have been explored, they tend to use kinetic resolutions, implying a maximum yield of 50%.[2] Only a few enzymes, including aminotransferases [3] and aminomutases,[4] have been used in asymmetric synthesis of this class of compounds. ...
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