Journal of the American Chemical Society 2005-09-28

A route to annulated indoles via a palladium-catalyzed tandem alkylation/direct arylation reaction.

Cyril Bressy, Dino Alberico, Mark Lautens

Index: J. Am. Chem. Soc. 127(38) , 13148-13149, (2005)

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Abstract

A norbornene-mediated palladium-catalyzed tandem alkylation/C-H functionalization sequence is described, in which an alkyl-aryl bond and a heteroaryl-aryl bond are formed in one pot. A variety of highly substituted six- and seven-membered ring annulated indoles were synthesized in good yields from bromoalkyl indoles and aryl iodides.

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