Journal of the American Chemical Society

Pyrimidine Nuclear Organometallic Compounds. The Synthesis of 6-Acyluracils and Orotic Acid-C14O2H

BW Langley

Index: Langley Journal of the American Chemical Society, 1956 , vol. 78, p. 2136,2140

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Citation Number: 36

Abstract

The preparation of 2, 4-diethoxy-6-pyrimidylmagnesium bromide and 2,~-dietlioxy-G- pyrinlid~ llitl1iurn is described. 2, 4-Diethoxy-6-pyrimidylcarbinols obtained from the latter have been converted by successive oxidation and hydrolysis into 6-acyluracils. Carbonation of the lithium compound with C1* O~ and hydrolysis of the product gave orotic acid-C1lOzH.