New triazole antifungal agents derived from mercaptomethylisoxazoles

…, Y Arredondo, R Pleixats, M Teixido…

Index: Moreno-Manas; Arredondo; Pleixats; Teixido; Raga; Palacin; Castello; Ortiz Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 6 p. 1557 - 1560

Full Text: HTML

Citation Number: 29

Abstract

Abstract Several new triazole antifungal agents derived from mercaptomethylisoxazoles of general structure 2 (2, 4-dihalogenophenyl)-3-((X-isoxazolyl) methylthio)-(1, 2, 4-triazol-1-yl)- 2-propanol, as well as some selected sulfoxides and sulfones derived thereof, have been synthesized and tested for antifungal activity. Some of these compounds showed good activity against yeasts and dermatophytes.