The 1, 2, 4-Thiadiazine Ring System. I. The Synthesis of 1, 2, 4, 2H-Thiadiazine 3, 5 (4H, 6H)-dione-1, 1-dioxide1

RL Hinman, L Locatell Jr

Index: Hinman; Locatell Journal of the American Chemical Society, 1959 , vol. 81, p. 5655,5658

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Citation Number: 14

Abstract

1, 2, 4, 2H-Thiadiazine-3, 5 (4H, 6H)-dione-l, l-dioxide (I) has been synthesized via the sequence: sulfoacetic acid (111 1, chlorosulfonylacetic acid (V), ethyl sulfamylacetate (VII), carbethoxymethanesulfonylurea (VIb) and base-catalyzed ring closure of the last compound to I. The product I, which was characterized by analysis, neutralization equivalent arid infrared spectrum, is a stable, crystalline solid, resembling barbituric acid (11) in its ...